C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/89 (2006.01)
Patent
CA 2447021
Compounds according to formula (I) wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amico, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; X represents a straight or branched, saturated or unsaturated C1-12 hydrocarbon diradical, optionaly substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; Y represents a bond, O, C(O), S, S(O), S(O)2, C(O)O, NH, C(O)NH, OC(O) or NHC(O); Z represents an aromatic or non-aromatic heterocyclic radical with 5-12 ring atoms, optionally substituted with halogen, hydroxy, cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, aminoalkyl or straight or branched, saturated or unsaturated C1-4 hydrocarbon radical, optionally substituted with halogen, hydroxy,cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl or aminoalkyl; provided that R1 is not attached to the nitrogen-atom in the pyridyl ring, and pharmaceutically acceptable salts, solvates, hydrates, N- oxides and prodrugs thereof are disclosed. The compounds are useful in therapy.
L'invention concerne des composants de formule (I) dans laquelle R1 représente l'hydrogène, l'halogène ou un ou plusieurs radical/radicaux hydrocarbure(s) simple(s) ou ramifié(s), saturé(s) ou non-saturé(s) C¿1-6?, éventuellement substitué(s) par halogène, hydroxy, cyano, nitro, carboxy, alcoxy, alcoxycarbonyl, alkylcarbonyl, formyl, amico, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy ou phosphono; X représente un diradical hydrocarbure C¿1-12? Simple ou ramifié, saturé ou non-saturé, éventuellement substitués par halogène, hydroxy, cyano, nitro, carboxy, alcoxy, alcoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy ou phosphono; Y représente une liaison, O, C(O), S, S(O), S(O)¿2?, C(O)O, NH, C(O)NH, OC(O) ou NHC(O); Z représente un radical hétérocyclique aromatique ou non-aromatique doté de 5 à 12 atome(s) de cycle, éventuellement substitués par halogène, hydroxy, cyano, nitro, alcoxy, alcoxycarbonyl, alkylcarbonyl, formyl, aminoalkyl ou un radical hydrocarbure C¿1-4? simple ou ramifié ou, saturé ou non-saturé, éventuellement substitué par halogène, à condition que R1 ne soit pas fixé à l'atome-azote sur le cycle pyridyl et des sels pharmaceutiquement acceptables, des solvats, des hydrates, des oxydes-N et des promédicaments de ceux-ci. Ces composants servent en thérapie.
Borden Ladner Gervais Llp
Leo Pharma A/s
LandOfFree
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