Pyridyl derivatives and their use as therapeutic agents

Details Pyridyl derivatives and their use as therapeutic agents Pyridyl derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/496 (2006.01) A61P 3/06 (2006.01) C07D 401/14 (2006.01) C12N 9/99 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2533898

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

La présente invention concerne des méthodes permettant de traiter une maladie ou une affection induite par des SCD chez un mammifère, de préférence, chez un humain. Les méthodes décrites dans cette invention consistent à administrer à un mammifère qui le nécessite un composé représenté par la formule (I): dans cette formule, W, V, x, y, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?7¿a, R?8¿, R?8¿a, R?9¿, R?9a¿, R?10¿ et R?10a¿ sont tels que définis dans le dossier. Cette invention concerne également des compositions pharmaceutiques contenant les composés représentés par la formule (I).

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