Pyridyl derivatives as cftr modulators

Details Pyridyl derivatives as cftr modulators Pyridyl derivatives as cftr modulators

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 43/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2718310

The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, of formula (I), and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

La présente invention concerne des modulateurs des transporteurs de la cassette de liaison à lATP (« ABC ») ou leurs fragments, y compris le régulateur de la conductance transmembranaire de la fibrose kystique (« CFTR »), leurs compositions, de formule (I) et des procédés associés. La présente invention concerne également des procédés de traitement de maladies médiées par le transporteur ABC qui utilisent de tels modulateurs.

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