C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/444 (2006.01) A61P 11/00 (2006.01) A61P 13/02 (2006.01) A61P 17/04 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2534905
There are disclosed novel pyridyl piperazinyl ureas that are potent antagonists of vanilloid receptor, VR1, and are useful for the treatment and/or prevention of i) acute or chronic pain or itch; ii) inflammation; iii) gastrointestinal and urinary tract disorders; and iv) tracheobronchial and diaphragmatic dysfunction in humans.
L'invention a trait à des urées pyridyle pipérazinyle, qui sont des antagonistes efficaces du récepteur vanilloïde, VR1, et sont utiles pour traiter et/ou prévenir : i) les douleurs ou démangeaisons aiguës ou chroniques ; ii) les inflammations ; iii) les troubles gastro-intestinaux et des voies urinaires ; et iv) les dysfonctionnements trachéo-bronchiques et diaphragmatiques chez les humains.
Carruthers Nicholas I.
Shah Chandravadan R.
Swanson Devin M.
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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