C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/4439 (2006.01) A61P 31/12 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2494164
The present invention relates to pyridyl substituted heterocycles according to structural formula (I) or (II), or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof, wherein: the B ring is an aromatic or nonaromatic ring that includes from one to four heteroatoms, wherein X, Y, Z are each, independently of one another selected from C, CH, N, NR16, NR18, S or O, provided that X and Y are not bothe O; U and T are each, independently of one another, selected from C, CH or N; Z is N or CH-; A is N or -CR2-; B is N or -CR3-; D is N or -CR4-; E is N or -CR5 -; G is N or -CR6-; and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the pyridyl heterocycles and hydro isomers thereof and/or pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
L'invention porte sur des hétérocycles à substitution pyridyle et leurs hydroisomères, et sur des compositions pharmaceutiques les contenant qui inhibent la réplication et/ou la prolifération du virus de l'hépatite C. L'invention porte également sur l'utilisation desdits hétérocycles à substitution pyridyle et de leurs hydroisomères, et/ou sur des préparations pharmaceutiques les comprenant servant à prévenir ou traiter les infections par le virus de l'hépatite C.
Goff Dane
Lu Henry H.
Partridge John
Singh Rajinder
Riches Mckenzie & Herbert Llp
Rigel Pharmaceuticals Inc.
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