Pyridyl tricyclic compounds as farnesyl protein transferase...

Details Pyridyl tricyclic compounds as farnesyl protein transferase... Pyridyl tricyclic compounds as farnesyl protein transferase...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2477328

Disclosed are novel tricyclic compounds represented by the formula (1.0) and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1Ø Also disclosed are methods of treating cancer using the compounds of formula 1Ø

L'invention concerne des composés tricycliques représentés par la formule (1.0) et un de leurs sels ou solvates, acceptable sur le plan pharmaceutique. Ces composés sont utiles pour inhiber la farnésyl protéine transférase. L'invention concerne aussi des compositions pharmaceutiques comprenant des composés de formule (1.0). Elle concerne enfin des méthodes de traitement du cancer au moyen des composés de formule (1.0).

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