C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/57 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) C07D 213/56 (2006.01) C07D 213/59 (2006.01) C07D 213/61 (2006.01) C07D 213/66 (2006.01) C07D 213/80 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2298480
Compounds represented by general formula (I), and nephritis remedies and TGF- .beta. inhibitors containing the same, wherein Ar1 is (substituted) pyridyl; Ar2 is (substituted) phenyl; R1 is H, alkyl or aryl; R2 is H, alkyl, cyano or alkoxycarbonyl; R3 is H or (substituted) alkyl; X is O or S; A and B are each H, OH, alkoxy or alkylthio, or alternatively they together form oxo, thioxo, =N-Y (wherein Y is dialkylamino, OH, aralkyloxy or alkoxy) or -Z1-M-Z2- (wherein Z1 and Z2 are each O, S or optionally alkyl-substituted imino; and M is alkylene or phenylene), or B may be 1-alkylimidazol-2-yl with A being OH; and n is an integer of 1 to 3.
L'invention concerne des composés de la formule (I), des remèdes contre la néphrite et des inhibiteurs de TGF-bêta contenant lesdits éléments. Dans ladite formule, Ar?1¿ est pyridyle (substitué); Ar?2¿ est phényle (substitué); R?1¿ est H, alkyle ou aryle; R?2¿ est H, alkyle, cyano ou alcoxycarbonyle; R?3¿ est H ou alkyle (substitué); X est O ou S; A et B sont l'un et l'autre H, OH, alcoxy ou alkylthio, ou forment, dans une composition différente, oxo, thioxo, =N-Y (Y étant dialkylamino, OH, aralkyloxy ou alcoxy) ou -Z?1¿-M-Z?2¿- (Z?1¿ et Z?2¿ étant l'un et l'autre O, S ou éventuellement imino alkyle-substitué; et M est alkylène ou phénylène), ou B peut être 1-alkylimidazole-2-yle, A étant OH; et n est un entier compris entre 1 et 3.
Hasegawa Yoshihiro
Hattori Tomohisa
Hayakawa Hiroyuki
Horiuchi Fumiko
Kumazawa Hiroaki
Smart & Biggar
Tsumura & Co.
LandOfFree
Pyridylacrylamide derivatives and nephritis remedies and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyridylacrylamide derivatives and nephritis remedies and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridylacrylamide derivatives and nephritis remedies and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1532776