Pyridyloxyindoles inhibitors of vegf-r2 and use thereof for...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2745922

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or hu-man body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of prolifera-tive diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

L'invention se réfère à de nouveaux composés organiques représentés par la formule (I) et à leur utilisation pour traiter des êtres humains ou des animaux, ainsi qu'à des compositions pharmaceutiques comprenant un composé représenté par la formule I et à l'utilisation d'un tel composé pour élaborer des compositions pharmaceutiques destinées à traiter des maladies dépendant de protéines kinases, en particulier des maladies prolifératives, par exemple pour traiter des tumeurs et des maladies oculaires néovasculaires.

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