Pyridylpyrrole derivatives

Details Pyridylpyrrole derivatives Pyridylpyrrole derivatives

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/44 (2006.01) A61K 31/54 (2006.01) C07D 411/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2310046

Object: to provide compounds having an inhibitory effect on the production of inflammatory cytokines. Constitution: compounds having general formula (I), pharmacologically acceptable salts thereof or derivatives of the same, wherein A: single bond, oxygen, sulfur, CO, SO, SO2, C(R9)(R10) [R9, R10: H, OH, halogeno, alkyl], N(R11), C=NOR11 [R11: H, alkyl]; D: single bond, C(R12)(R13) [R12, R13: H, OH, halogeno, alkyl]; R1: optionally substituted pyridyl; R2: optionally substituted phenyl; R3: halogeno, alkyl, haloalkyl, alkoxy, haloalkoxy; R4, R5, R6, R7, R8: H, alkyl; k: 0-3; and m: 1, 2.

L'invention concerne des composés de la formule générale (I), des sels pharmaceutiquement acceptables ou des dérivés desdits composés. Dans ladite formule, A est une liaison simple, oxygène, soufre, CO, SO, SO¿2?, C(R?9¿)(R?10¿) [R?9¿, R?10¿: H, OH, halogéno, alkyle], N(R?11¿), C=NOR?11¿ [R?11¿: H, alkyle]; D est une liaison simple, C(R?12¿)(R?13¿) [R?12¿, R?13¿: H, OH, halogéno, alkyle]; R?1¿ est pyridyle éventuellement substitué; R?2¿ est phényle éventuellement substitué; R?3¿ est halogéno, alkyle, haloalkyle, alcoxy, haloalcoxy; R?4¿, R?5¿, R?6¿, R?7¿, R?8¿: H, alkyle; k est compris entre 0 et 3; et m est 1, 2. Lesdits composés ont un effet inhibiteur sur la production de cytokines inflammatoires.

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