Pyridylsulfonamido pyrimidines for treating diabetic...

Details Pyridylsulfonamido pyrimidines for treating diabetic... Pyridylsulfonamido pyrimidines for treating diabetic...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2517930

The present invention relates to the use of a compound of formula (I) wherein R1 is pyridyl or thiazolyl, any of which may optionally be substituted with C1- 8alkyl or C2-8alkenyl; and a) R2 is methoxy and n is zero or one; or b) R2 is chlorine and n is zero and pharmaceutically acceptable salts thereof for lowering or controlling proteinuria, in particular for the treatment of diabetic nephropathy.

L'invention concerne un composé de formule (I), dans laquelle R1 représente pyridyle ou thiazolyle, chacun pouvant être éventuellement substitué par alkyle C1-8 ou alcényle C2-8 ; et a) R2 représente méthoxy et n représente zéro ou un ; ou b) R2 représente chlore et n représente zéro. L'invention concerne également leurs sels pharmaceutiquement acceptables. Lesdits composés sont utilisés pour diminuer ou pour contrôler la protéinurie, et ils sont utilisés, en particulier, dans le traitement de la néphropathie.

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