Pyrimidin-2-ylamino derivatives and their use to treat...

Details Pyrimidin-2-ylamino derivatives and their use to treat... Pyrimidin-2-ylamino derivatives and their use to treat...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2745297

Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is formula (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.

L'invention concerne des composés de formule (I) qui modulent la JNK dans laquelle X1 et X2 représentent chacun indépendamment N ou CH ; X3 représente CH-R2 ou N-SO2R, où R représente un groupe alkyle inférieur ; R1 représente un groupe aryle ou hétéroaryle, substitué par 0 à 3 radicaux d'alkyle inférieur ; R2 est de formule (II), où R3 représente H, un groupe acyle inférieur ou un acide aminé, ou l'un de leurs sels pharmaceutiquement acceptables.

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