Pyrimidine-2,4-diamine derivatives and their use as jak2...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 295/088 (2006.01) C07D 295/135 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2679489

Pyrimidine-2,4-diamines derivatives having activity as JAK2 kinase inhibitors are disclosed, as well as pharmaceutical compositions and methods for using the same in the treatment of cancer and other JAK2 kinase-associated conditions.

La présente invention concerne des dérivés de pyrimidine-2,4-diamine possédant une activité en tant qu'inhibiteurs de la kinase Jak2, ainsi que des compositions pharmaceutiques et des procédés pour les utiliser dans le traitement d'un cancer et d'autres affections associées à la kinase Jak2.

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