C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/00 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 451/04 (2006.01) C07D 487/08 (2006.01) C07D 491/08 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2715658
This invention is directed to compounds of formula (I): where, n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
L'invention concerne des composés représentés par la formule (I) : où n, m, Y, R1, R2, R3, R4 et R5 sont décrits dans les présentes comme des stéréoisomères ou des mélanges de ces éléments, ou comme des sels pharmaceutiquement acceptables de ceux-ci ; des compositions pharmaceutiques contenant les composés représentés par la formule (I) ; et des procédés d'utilisation des composés et des compositions pharmaceutiques pour le traitement d'affections ou d'états liés à l'activité des JAK2.
Argade Ankush
Atuegbu Andy
Bhamidipati Somasekhar
Clough Jeffrey
Darwish Ihab
Gowling Lafleur Henderson Llp
Rigel Pharmaceuticals Inc.
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