Pyrimidine 2'-methylidene nucleoside compounds

Details Pyrimidine 2'-methylidene nucleoside compounds Pyrimidine 2'-methylidene nucleoside compounds

C - Chemistry, Metallurgy

07

H

260/210, 260/229

C07H 19/073 (2006.01) C07H 19/06 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2004752

Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: Image wherein R1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R3 and R4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R1 is amino or hydroxy, and both R3 and R4 are hydrogen. These compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.

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