Pyrimidine-2-sulphides and their s-oxides for use in...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01)

Patent

CA 1200495

ABSTRACT A pharmaceutical composition comprising as active ingredient a com- pound of the formula:- Image [wherein X represents a fluorine, chlorine or bromine atom; n is 1 or 2; R1 and R2, which may be the same or different, each represents a hydrogen atom or a C1-4 alkyl group, a carboxyl group or a group of the formula -COORa (in which Ra represents a C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl group, a C3-8 cycloalkyl or C3-8 cycloalkenyl group, an araliphatic group with up to 4 carbon atoms in the aliphatic moiety, which moiety may be saturated or un- saturated, and up to 10 carbon atoms in the aryl moiety or a C6-10 aryl group, the aryl moiety or group being optionally substituted by a C1-4 alkyl group); and R3 represents an unsubstituted C1-8 alkyl or C3-8 cycloalkyl group or an unsubstituted aralkyl group with up to 4 carbon atoms in the alkyl moiety and up to 10 carbon atoms in the aryl moiety or an unsubstituted C6-10 aryl group, the aryl moiety or group optionally carrying a C1-4 alkyl group] or, where an acidic group is present, a physiologically compatible salt thereof, in association with a pharmaceutical carrier or excipient. The compositions are of interest in combating abnormal cell proliferation.

440611

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