Pyrimidine and pyridine derivatives as posh and posh-ap...

Details Pyrimidine and pyridine derivatives as posh and posh-ap... Pyrimidine and pyridine derivatives as posh and posh-ap...

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07D 213/75 (2006.01)

Patent

CA 2734710

Pyridine and pyrimidine derivatives inhibit ubiquitination of human polypeptides, particularly of POSH and POSH- associated proteins such as HERPUD1, and can be used as medicaments for treatment of viral infections caused by virus such as HIV and for treatment of neurological disorders or diseases.

L'invention porte sur des dérivés de pyridine et de pyrimidine qui inhibent l'ubiquitination de polypeptides humains, en particulier de POSH et de protéines associées au POSH telles que HERPUD1, et qui peuvent être utilisés en tant que médicaments pour le traitement d'infections virales provoquées par un virus tel que le VIH et pour le traitement de troubles ou de maladies neurologiques.

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