Pyrimidine and triazine kinase inhibitors

Details Pyrimidine and triazine kinase inhibitors Pyrimidine and triazine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/53 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07D 251/52 (2006.01) C07D 251/54 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2394727

Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula (I). As selective inhibitors of inappropriate kinase activities, the compounds of the present invention are useful in the treatment of conditions associated with such activity, including, but not limited to, inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting inappropriate kinase activities and methods of treating conditions associated with such activities.

On décrit des composés qui inhibent sélectivement des activités kinase inappropriées et des procédés de préparation de ces derniers. Dans une forme de l'invention, les composés sont représentés par la formule (I). En tant qu'inhibiteurs d'activités kinase inappropriées, les composés selon l'invention sont utiles dans le traitement de pathologies associées à une telle activité, et comprenant entre autres c'est-à-dire sans caractère limitatif, les réponses inflammatoires et auto-immunes, le diabète, l'asthme, le psoriasis, la maladie intestinale inflammatoire, le rejet des greffes et les métastases de tumeur. On décrit également des procédés d'inhibition des activités kinase inappropriées et des procédés de traitement de maladies ou de troubles associés à ces activités.Formule (I)

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