C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 475/00 (2006.01) C07D 475/10 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2469316
The present invention provides a compound of formula (I): (I), or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders, such as diabetes, cancer, stroke and Alzheimer~s disease.
La présente invention a trait à un composé représenté par la formule (I), ou à un dérivé pharmaceutiquement acceptable dudit composé. Ces composés sont des inhibiteurs des protéines kinases, en particulier des protéines kinases de mammifère GSK-3. L'invention se rapporte également à des compositions pharmaceutiquement acceptables contenant les composés de l'invention, et à des procédés d'utilisation desdits composés et compositions dans le traitement de divers troubles causés par les protéines kinases, tels que le diabète, le cancer, les accidents vasculaires cérébraux et la maladie d'Alzheimer.
Choquette Deborah
Davies Robert J.
Wannamaker Marion W.
Robic
Vertex Pharmaceuticals Inc.
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