Pyrimidine carboxamides and related compounds and methods...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/28 (2006.01) A61K 31/495 (2006.01) C07D 239/30 (2006.01) C07D 239/34 (2006.01) C07D 239/42 (2006.01) C07D 241/24 (2006.01) C07D 401/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2230894

Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immuno-inflammatory and autoimmune diseases are disclosed. The compounds are pyrimidine- or pyrazine- containing compounds and, in one embodiment, are carboxyamides of the same. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof and effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

Composés présentant une utilité comme agents anti-inflammatoires en général, et plus spécifiquement, pour la prévention et/ou le traitement des maladies immuno-inflammatoires et auto-immunes. Ces composés sont des composés contenant de la pyrimidine ou de la pyrazine, et dans un mode de réalisation, sont des carboxyamides de ces substances. Sont décrites également des méthodes de prévention et/ou de traitement d'états inflammatoires par l'administration à un animal ayant besoin d'un tel traitement d'une quantité efficace d'un composé de cette invention, de préférence sous la forme d'une préparation pharmaceutique.

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