C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/34 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/538 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 1/08 (2006.01) A61P 1/10 (2006.01) A61P 1/12 (2006.01) A61P 1/14 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/14 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/02 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01
Patent
CA 2757188
[Problems] Provided is a novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. [Means for Solution] It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like, thereby the present invention was completed.
L'invention porte sur un procédé nouveau et excellent pour prévenir et/ou traiter des maladies liées au récepteur cannabinoïde 2, qui est basé sur une action agoniste sur les récepteurs canabinoïdes 2. L'invention porte spécifiquement sur un dérivé hétérocyclique ayant principalement deux substituants, par exemple, un dérivé amide d'acide pyrimidine-5-carboxylique ayant un groupe amino substitué en position 2, qui a une forte action agoniste sur les récepteurs cannabinoïdes 2. Le dérivé peut être un agent pour prévenir et/ou traiter des maladies liées au récepteur cannabinoïde 2, telles que des maladies inflammatoires et des douleurs.
Hamaguchi Hisao
Hondo Takeshi
Kubota Hirokazu
Matsushima Yuji
Nishigaki Fusako
Astellas Pharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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