Pyrimidine compound

Details Pyrimidine compound Pyrimidine compound

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2146333

A pyrimidine derivative represented by the formula (II) or (III): Image (II) Image (III) (wherein R1 and R2 each represent H, a halogen, amino, nitro, an unsubstituted or substituted alkyl, an alkoxy or an alkoxycarbonyl, or R1 and R2 are bonded together to form an unsubstituted or substituted alkylene; R3 represents an aralkyl or a hetero aromatic ring type-alkyl, R4 represents H or acyl, R5 represents H, OH or an alkoxy, R6 represents H, a halogen, an alkyl or an alkoxy, X represents -CH=, -CH=CH-(CH2)p-, -CH2- or -CH2CH2-(CH2)p-, Y represents =CH- (CH2)p-, -CH2-(CH2)p-, a single bond or a double bond, p represents 0 or 1, and ? represents a single bond or a double bond), and a salt thereof have selective acetylcholinesterase- inhibiting activities and selective A type monoamine oxidase-inhibiting activities, and are useful as an anti- depressant and an agent for curing senile dementia.

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