Pyrimidine compound crystal or amorphous form and process...

Details Pyrimidine compound crystal or amorphous form and process... Pyrimidine compound crystal or amorphous form and process...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2596737

Crystal of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1- methylpyridin-2(1H)-one exhibiting, in powder X-ray diffractometry, diffraction peaks at diffraction angles (2.theta.~0.2~) of 9.7~ and/or 21.9~. This crystal is suitable for use as an active ingredient of preventive/therapeutic agents for diseases, such as costiveness. Further, a hydrate of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1- methylpyridin-2(1H)-one and 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1- methylpyridin-2(1H)-one in amorphous form are also suitable for use as an active ingredient of preventive/therapeutic agents for diseases, such as costiveness.

L~invention décrit un cristal de la 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-méthylpyridin-2(1H)-one présentant, lors d~une analyse par diffraction X sur poudre, des pics de diffraction aux angles de diffraction (2.theta. ± 0,2°) 9,7° et/ou 21,9°. Ce cristal est approprié pour être utilisé en tant que principe actif dans des agents préventifs/thérapeutiques pour des troubles tel que la production de scybales. En outre, un hydrate de la 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-méthylpyridin-2(1H)-one et la 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-méthylpyridin-2(1H)-one sous sa forme amorphe sont également appropriés pour être utilisés en tant que principe actif dans des agents préventifs/thérapeutiques pour des maladies telles que la production de scybales.

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