Pyrimidine compounds, processes for the preparation thereof...

Details Pyrimidine compounds, processes for the preparation thereof... Pyrimidine compounds, processes for the preparation thereof...

C - Chemistry, Metallurgy

07

D

C07D 239/36 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 1/02 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) C07D 405/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2385292

Pyrimidine derivatives of general formula (I) or nontoxic salts thereof, useful as intermediates for the synthesis of drugs and/or as drugs, particularly elastase inhibitors. In formulas (I) and (II) R1 is H or F; R2 is -CH(OR3)2, CHO, COOH, alkoxycarbonyl, furan-2-yl, a group of general formula (II), or the like; R3 is Me or Et; and R4 is alkyl, phenyl, (substituted) benzyl, or the like.

L'invention porte sur des dérivés de la pyrimidine de formule générale (I) ou leurs sels non toxiques servant d'intermédiaires de synthèse de médicaments et/ou de médicaments, en particulier d'inhibiteurs de l'élastase. Dans la formule (I), R?1¿ est H ou F; R?2¿ est -CH(OR?3¿)¿2?, CHO, COOH, alcoxycarbonyle, furan-2-yle, un groupe de formule générale (II), ou analogues; R?3¿ est Me ou Et; et R?4¿ est alkyle, phényle, benzyle (substitué), ou analogues.

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