Pyrimidine compounds used in the therapy

Details Pyrimidine compounds used in the therapy Pyrimidine compounds used in the therapy

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2140018

Compounds of formula (1), wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl or acyl, R5 is alkyl, X represents a hydrophobic substituent and n is an integer from 1 to 3, and R6 and R7 each represent alkyl, cycloalkyl, or aral- kyl, or R6 and R7 together with the nitrogen to which they are attached form a heterocyclic ring, with the proviso that one or both of R6 and R7, or the heterocyclic ring including R6 and R7, carries and/or includes at least one oxygen or sulphur at- om, or a salt or N-oxide thereof may be used in the treatment of P.Carinii infections.

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