Pyrimidine derivates for the treatment of abnormal cell growth

Details Pyrimidine derivates for the treatment of abnormal cell growth Pyrimidine derivates for the treatment of abnormal cell growth

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) C07D 209/00 (2006.01) C07D 211/00 (2006.01) C07D 239/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2510848

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, n, A and B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

L'invention concerne des composés de formule (1) et des sels pharmaceutiquement acceptables, des promédicaments et des solvates desdits composés. Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, n, A et B ont la définition mentionnée dans la description. L'invention concerne également des procédés de traitement du développement anormal de cellules chez des mammifères, par administration desdits composés de formule 1 et des compositions pharmaceutiques pour traiter de tels troubles, qui contiennent les composés de formule 1. L'invention concerne en outre des procédés de préparation des composés de formule 1.

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