Pyrimidine derivative as pi3k inhibitor and use thereof

Details Pyrimidine derivative as pi3k inhibitor and use thereof Pyrimidine derivative as pi3k inhibitor and use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2659604

Disclosed is a medical agent which is excellent in stability in living bodies and water solubility, while having excellent PI3K inhibitory activity. The medical agent is thus useful for prevention or treatment of cancers. Specifically disclosed is a compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (I) (In the formula, X represents a single bond or the like; Y represents a single bond or the like (provided that X and Y are not single bonds at the same time); Z represents a hydrogen atom or the like; m represents an integer of 1 or 2; and R1 represents a cyclic substituent.)

L'invention concerne un agent médical qui présente des propriétés excellentes de stabilité dans des organismes vivants et de solubilité dans l'eau tout en ayant une excellente activité d'inhibition de la PI3K. Cet agent médical est donc utile pour la prévention ou le traitement de cancers. Spécifiquement, l'invention concerne un composé représenté par la formule (I) ci-dessous ou un de ses sels pharmaceutiquement acceptables. (I) (Dans la formule, X représente une liaison simple ou similaire ; Y représente une liaison simple ou similaire (à la condition que X et Y ne soient pas en même temps des liaisons simples) ; Z représente un atome d'hydrogène ou similaire ; m est un nombre entier valant 1 ou 2 ; et R1 représente un substituant cyclique.)

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