Pyrimidine derivatives

Details Pyrimidine derivatives Pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/242

C07D 513/04 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) C07D 239/48 (2006.01)

Patent

CA 1324788

PYRIMIDINE DERIVATIVES Abstract The compounds of the general Formula I Image (I) and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I A stands for -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CH2-CH2CH2- or -CH=CH-: R4 is hydrogen, C1-4 alkyl or optionally substituted phenyl; r is 0, 1, 2, 3 or 4; R1 stands for hydrogen or C1-5 alkanoyl; R2 represents hydrogen, C1-5 alkanoyl or a group of the general Formula (a) Image (a) - 2 - wherein R stands for hydrogen, C1-4 alkyl, C2-4 alkenyl, phenyl or phenyl-C1-3 alkyl and R3 stands for hydrogen. The compounds of the general Formula I can be prepared by reacting a 2-mercapto-4,6-diamino-pyrimidine of the general Formula II Image (II) with a dihalo compound of the general Formula III Image (III) (wherein Y and Z are halogen).

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