Pyrimidine derivatives

Details Pyrimidine derivatives Pyrimidine derivatives

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/067 (2006.01) A61K 31/70 (2006.01) C07D 239/36 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07D 495/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01)

Patent

CA 1339313

Compounds of the formula (see fig. I) wherein R1 is OH, NH2; R2 is a heteroaromatic or aromatic substituent as defined in claim 1; R3 is H, OH, F, OCH3; R4 is H, F, OH or an ether or ester residue thereof, OCH3, CN, C~CH, N3; R5 is OH or an ether or ester residue thereof including mono-, di- and triphosphate esters; (see fig II), (see fig. III), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic and/or prophylactic treatment of virus infections such as AIDS. Compounds of the formula (see fig. 4) wherein R1 and R2 are as defined above, are new precursor compounds.

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