Pyrimidine derivatives

Details Pyrimidine derivatives Pyrimidine derivatives

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/073 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01)

Patent

CA 1303031

RAN 4430/20 Abstract Compounds of the formula Image wherein R1 is halogen, C1-4-alkyl, halo-(C1-4-alkyl) or C2-4-alkanoy1, R2 is hydrogen, hydroxy, C1-4-alkoxy, C1-4-alkylthio or phenyl-(C1-4-alkoxy) or, when X is O, also acyloxy, R3 is hydrogen or C1-4-alkyl, R4 is a carbocyclic group or a heterocyclic group, RS is hydrogen or fluorine, m stands for zero, 1 or 2, X is O or NH and Y is a direct bond, -CH=CH-, -C=C- or a group of the formula of (Z)n-A- (a) in which A is a C1-8-alkylene group which is optionally substituted by one or two phenyl groups, Z is O, S, SO or SO2 and n stands for zero or 1, with the proviso that R1 is different from iodine, when R2 is hydroxy or benzoyloxy, R3 is hydrogen, R4 is unsubstituted phenyl, R5 is hydrogen, m stands for zero, X is O, and Y is a direct bond, and tautomers thereof, possess antiviral activity and can be used in the form of medicaments for the control and prevention of viral infections. They can be manufactured according to methods known per se.

543985

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