C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2578122
The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above- mentioned diseases and disorders.
La présente invention concerne des dérivés de pyrimidine, des procédés pour les synthétiser, ainsi que leur utilisation comme agents à activité pharmaceutique, notamment pour prévenir et/ou traiter des troubles de la prolifération cellulaire, des cancers, des leucémies, des dysfonctionnements érectiles, des maladies et des troubles cardio-vasculaires, des maladies inflammatoires, des rejets de transplant, des maladies immunologiques, des maladies neuro-immunologiques, des maladies auto-immunes, des maladies infectieuses, notamment des infections opportunistes, des maladies à prions et/ou une neuro-dégénération. De plus, cette invention concerne des compositions pharmaceutiques comprenant au moins un dérivé de pyrimidine et/ou des sels de celui-ci, acceptables d'un point de vue pharmaceutique, comme ingrédient actif avec au moins un support, un excipient ou des diluants, acceptables d'un point de vue pharmaceutique, ainsi que des procédés pour prévenir et/ou traiter lesdites maladies et lesdits troubles.
Baumann Matthias
Brehmer Dirk
Daub Henrik
Hoppe Edmund
Keri Gyoergy
Borden Ladner Gervais Llp
Gpc Biotech Ag
Vichem Chemie Kft
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