Pyrimidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/42 (2006.01) A61K 31/506 (2006.01) C07D 239/47 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2382605

The invention concerns pyrimidine derivatives of Formula (I) wherein m is 0-3 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R3 is hydrogen, halogeno or (1-6C)alkyl; n is 0-2 and each R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; p is 0-4; and Q1 is aryl or heteroaryl; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

L'invention concerne des dérivés de pyrimidine de formule (I) dans laquelle m est compris entre 0 et 3 et chaque R?1¿ représente un groupe hydroxy, halogéno, trifluorométhyle ou cyano, R?3¿ représente hydrogène, halogéno ou alkyle C1-6, n est compris entre 0 et 2 et chaque R?2¿ représente un groupe hydroxy halogéno, trifluorométhyle ou cyano, p est compris entre 0 et 4, et Q?1¿ représente aryle ou hétéroaryle, ou des sels pharmaceutiquement acceptables ou des esters clivables in vivo de ces derniers. L'invention concerne également des procédés de préparation des dérivés, des compositions les renfermant et leur utilisation dans le traitement de maladies ou de conditions médicales induites par les cytokines.

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