C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2640375
The invention concerns benzamide compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, ring A, n, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4, and/or EphA2 and/or Src kinases.
La présente invention concerne des composés de benzamide de Formule (I) ou un sel dérivé pharmaceutiquement acceptable, où R1, le cycle A, n, R3, et R4 sont tels qu~énoncés dans la description. La présente invention a aussi trait à des processus de préparation de tels composés, à des compositions pharmaceutiques les contenant et à leur utilisation dans la fabrication d~un médicament à utiliser comme agent antiproliférateur pour la prévention ou le traitement de tumeurs ou d~autres conditions prolifératrices qui sont sensibles à l~inhibition des kinases EphB4, et/ou EphA2 et/ou Src.
Barlaam Bernard Christophe
Ducray Richard
Kettle Jason Grant
Lambert-Van Der Brempt Christine Marie Paul
Leach Andrew
Astrazeneca Ab
Fetherstonhaugh & Co.
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