C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2693880
A compound of formula (I) where one of A1, A2 or A3 is N, and the others are independently selected from CH or N; ring B is a fused 5 or 6-membered carbocyclic or heterocyclic ring which is optionally substituted as defined in the specification, and R1, R2, R3, R4, and n are as defined in the specification. The compounds are inhibitors of EphB4 orEphA2 and therefore may be useful in pharmaceutical compositions for the treatment of conditions such as cancer.
La présente invention concerne un composé de formule (I) dans laquelle un parmi A1,A2 ou A3 est N, et les autres sont indépendamment choisis parmi CH ou N ; le noyau B est un noyau accolé carbocylique ou hétérocyclique de 5 ou 6 chaînons éventuellement substitué tel que défini dans la description, et R1, R2, R3, R4, et n sont tels que définis dans la description. Les composés sont inhibiteurs de EphB4 ou EphA2 et peuvent donc être utiles dans des compositions pharmaceutiques pour le traitement de conditions tel que le cancer.
Barlaam Bernard Christophe
Ducray Richard
Kettle Jason Grant
Astrazeneca Ab
Fetherstonhaugh & Co.
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