C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2558915
The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson~s disease, epilepsy, and addiction.
La présente invention porte sur de nouveaux composés de pyrimidine substitués de la formule (I) : faisant office d~antagonistes récepteurs MCH. Ces composés sont utiles dans des compositions pharmaceutiques dont le champ d~application regroupe la prophylaxie ou le traitement visant à améliorer la mémoire, le sommeil et le réveil, l'anxiété, la dépression, les troubles de l'humeur, les attaques, l~obésité, le diabète, les troubles de l~appétit et de l~alimentation, les maladies cardiovasculaires, l~hypertension, la dyslipidémie, l~infarctus du myocarde, la boulimie, l~anorexie, les troubles mentaux comme la maniaco-dépression, la schizophrénie, les délires, la démence, le stress, les troubles cognitifs, le manque d~attention, les abus de substances diverses et la dyskinésie comme la maladie de Parkinson, l~épilepsie et l~addiction.
Kanuma Kosuke
Kramer Bryan A.
Omodera Katsunori
Sekiguchi Yoshinori
Semple Graeme
Arena Pharmaceuticals Inc.
Taisho Pharmaceutical Co. Ltd.
Torys Llp
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