Pyrimidine derivatives as alk-5 inhibitors

Details Pyrimidine derivatives as alk-5 inhibitors Pyrimidine derivatives as alk-5 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/435 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2657227

Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

La présente invention concerne des composés de formule (I), libres ou sous forme de sels ou de solvates, dans laquelle T1, T2, Ra et Rb ont le sens indiqué dans le mémoire descriptif. Lesdits composés peuvent être utilisés pour traiter des troubles inflammatoires or obstructifs des voies aériennes, l'hypertension pulmonaire, la fibrose pulmonaire, la fibrose hépatique, des maladies musculaires et des troubles systémiques du squelette. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés de préparation des composés.

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