Pyrimidine derivatives as kinase inhibitors

Details Pyrimidine derivatives as kinase inhibitors Pyrimidine derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2729495

The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin- like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).

La présente invention concerne de nouveaux dérivés de pyrimidine et des compositions pharmaceutiques de ceux-ci, et des procédés dutilisation de tels composés. Par exemple, les dérivés de pyrimidine de linvention peuvent être utilisés pour traiter, améliorer ou prévenir une pathologie qui est influencée par linhibition du facteur de croissance insulinomimétique (IGF-1R) ou de la kinase de lymphome anaplasique (ALK).

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