Pyrimidine derivatives as mtor inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2755061

The invention relates to compounds of Formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

La présente invention concerne des composes de formule (I) dans laquelle X, R1, R2, T, m, n, o ont les significations telles que citées dans la description et les revendications. Lesdits composés sont utiles comme inhibiteurs du mTOR pour le traitement ou la prophylaxie de maladies et de troubles liés au mTOR. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, la préparation de tels composés ainsi leur utilisation comme médicaments.

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