Pyrimidine derivatives as protein kinase inhibitors

Details Pyrimidine derivatives as protein kinase inhibitors Pyrimidine derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2700979

The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof wherein: X is NR7; Y is O or N-(CH2)n R19 ; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4' are each independently H or alkyl; or R4 and R4' together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.

La présente invention porte sur un composé représenté par la formule VII(I), ou un sel ou ester pharmaceutiquement acceptable de ce composé, dans laquelle : X représente NR7; Y représente O ou N-(CH2)nR19; n représente 1, 2 ou 3; m représente 1 ou 2; R1 et R2 représentent chacun individuellement H, alkyle ou cycloalkyle; R4 et R4' représentent chacun individuellement H ou alkyle; ou R4 et R4' forment ensemble un groupe spirocycloalkyle; R19 représente H, alkyle, aryle ou un groupe cycloalkyle, R6 représente OR8 ou halogène; et R7 et R8 représentent chacun individuellement H ou alkyle. D'autres aspects portent sur des compositions pharmaceutiques comprenant lesdits composés et sur l'utilisation de celles-ci dans le traitement de troubles prolifératifs et similaires.

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