Pyrimidine derivatives as rho-kinase inhibitors

Details Pyrimidine derivatives as rho-kinase inhibitors Pyrimidine derivatives as rho-kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01) C07D 239/48 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2473510

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

L'invention concerne des composés et des dérivés de ces composés, leur synthèse et leur utilisation en tant qu'inhibiteurs de kinase Rho. Ces composés sont utiles concernant l'inhibition de croissance de tumeur, le traitement de dysfonctionnement érectile, et le traitement d'autres indications dont la médiation est assurée par la kinase Rho, par exemple, la coronaropathie.

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