Pyrimidine derivatives as selective inhibitors of cox-2

Details Pyrimidine derivatives as selective inhibitors of cox-2 Pyrimidine derivatives as selective inhibitors of cox-2

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2395049

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, C1-6alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl or C4- 12bridged cycloalkane; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

L'invention concerne des composés représentés par la formule (I) et leurs dérivés pharmaceutiquement acceptables. Dans ladite formule, R?1¿ et R?2¿ sont indépendamment choisis parmi H, C¿1-6?alkyle, C¿2-6?alcényle, C¿3-6?alcynyle, C¿3-10?cycloalkylC¿0-6?alkyle ou C¿4-12?cycloalcane ponté ; et R?3¿ représente C¿1-6?alkyle ou NH¿2?. Les composés représentés par la formule (I), qui sont de puissants inhibiteurs sélectifs de COX-2, sont utilisés dans le traitement de la douleur, de la fièvre et de l'inflammation associées à divers états pathologiques et maladies.

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