Pyrimidine derivatives exhibiting antitumor activity

C - Chemistry – Metallurgy – 07 – D

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C07D 417/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2336832

Compounds represented by general formula (I); prodrugs of the same; or pharmaceutically acceptable salts of both; or solvates of them. In said formula, R1, R2, R3 and R4 are each independently hydrogen, alkyl or the like; R5 and R6 are each independently hydrogen, alkyl or the like; X is -O-, -S- or the like; Y is a divalent group derived from a five-membered aromatic heterocycle, or the like; and Z is optionally substituted aryl or the like.

L'invention concerne des composés correspondant à la formule générale (I); des promédicaments à base de ces composés; ou des sels pharmaceutiquement acceptables de ces composés, ou leurs solvates, formule dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont chacun indépendamment hydrogène, alkyle ou similaire; R?5¿ et R?6¿ sont chacun indépendamment hydrogène, alkyle ou similaire; X est -O-, -S- ou similaire; Y est un groupe bivalent dérivé d'un hétérocycle aromatique à cinq éléments ou similaire et; Z est un aryle éventuellement substitué ou similaire

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