Pyrimidine derivatives for labeled binding partners

Details Pyrimidine derivatives for labeled binding partners Pyrimidine derivatives for labeled binding partners

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) C07D 239/46 (2006.01) C07D 239/70 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2309340

Compounds having structure (1) wherein R1 is -H a protecting group, a linker or a binding partner, and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods to make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.

L'invention concerne des composés de la structure (1) dans laquelle R<1> est -H, un groupe de protection, un lieur ou un partenaire de liaison; et R<2> et R<34> sont tels que définis dans la description. L'invention concerne en outre des intermédiaires et des procédés de préparation des composés de la structure (1), ainsi que des procédés pour utiliser lesdits composés comme marqueurs dans des méthodes diagnostiques et pour améliorer la liaison à des bases complémentaires.

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