Pyrimidine derivatives for the treatment of abnormal cell...

Details Pyrimidine derivatives for the treatment of abnormal cell... Pyrimidine derivatives for the treatment of abnormal cell...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2632149

The present invention relates to salts, solvates and substoichiometric solvates of N- [3-[[[2-[(2,3-dihy-dro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4- pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide. The invention also provides pharmaceutical compositions comprising such complexes, as well as methods of treating abnormal cell growth by administering the complexes of the invention.

La présente invention concerne des sels, des solvates et des solvates sous-stoechiométriques de N- [3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluorométhyl)-4-pyrimidinyl]amino]méthyl]-2-pyridinyl]-N-méthylméthanesulfonamide. L'invention concerne également des compositions pharmaceutiques comprenant ces complexes ainsi que des méthodes destinées à traiter la croissance cellulaire anormale par administration des complexes de l'invention.

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