C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/505 (2006.01) C07D 209/00 (2006.01) C07D 211/00 (2006.01) C07D 239/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2529611
The present invention relates to a compound of the formula (I), wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in thetreatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
La présente invention concerne un composé représenté par la formule générale (I), dans laquelle R<1>-R<4> désignent des éléments décrits dans la partie descriptive de la présente demande. Ces nouveaux dérivés de pyrimidine sont destinés au traitement de la croissance cellulaire anormale, telle que le cancer, chez des mammifères. L'invention concerne également une méthode d'utilisation de ces composés dans le traitement de la croissance cellulaire anormale chez des mammifères, en particulier chez des humains, ainsi que des compositions pharmaceutiques contenant ces composés.
Kath John Charles
Luzzio Michael Joseph
Pfizer Products Inc.
Smart & Biggar
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