C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 487/08 (2006.01) C07D 495/08 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2634646
The present invention relates to a compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a group of Formula (II) and salts thereof. Such pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
La présente invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de ce dernier, formule dans laquelle Ar est un groupe de formule (III), et R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, le sel dudit composé, R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p et q étant tels que définis. Ces nouveaux dérivés pyrimidiques sont utiles dans le traitement d'une croissance cellulaire anormale, telle que le cancer, chez des mammifères. Cette invention concerne également un procédé d'utilisation de ces composés dans le traitement d'une croissance cellulaire anormale chez des mammifères, en particulier des êtres humains, ainsi que des compositions pharmaceutiques contenant lesdits composés.
Arcari Joel Thomas
Bhattacharya Samit Kumar
Brosius Arthur Douglas
Luzzio Michael Joseph
Nelson Kendra Louise
Pfizer Products Inc.
Smart & Biggar
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