C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2564199
The present invention relates to a compound of the formula (1) wherein R1-R4 and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
La présente invention concerne un composé de formule (1), dans laquelle R?1¿ à R?4¿ et Ar sont tels que définis dans la description. Ces nouveaux dérivés de pyrimidine sont utiles dans le traitement d'une croissance cellulaire anormale, telle que le cancer, chez des mammifères. L'invention concerne également une méthode d'utilisation de ces composés dans le traitement d'une croissance cellulaire anormale chez des mammifères, et notamment chez l'homme, ainsi que des compositions pharmaceutiques contenant ces composés.
Kath John Charles
Luzzio Michael Joseph
Pfizer Products Inc.
Sim & Mcburney
LandOfFree
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