Pyrimidine derivatives for the treatment of abnormal cell...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2566707

The present invention relates to a compound of the formula (I) wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

L'invention concerne un composé de formule 1 dans laquelle R?1¿-R?4¿sont tels que définis dans le dossier. Lesdits dérivés sont utiles dans le traitement de la croissance cellulaire anormale, telle que le cancer, chez les mammifères. Elle porte également sur un procédé d'utilisation desdits composés dans le traitement de la croissance cellulaire anormale chez les mammifères, notamment l'homme, et sur des compositions pharmaceutiques contenant lesdits composés.

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