C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/506 (2006.01) A61K 31/5355 (2006.01) A61K 31/541 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2396324
A compound represented by the formula (I): (see formula I) wherein, for example, R1, R2, R3, and R4 are each independently hydrogen atom, alkyl, and the like, R5 and R6 are each independently hydrogen atom, alkyl, and the like, R B and R c are each independently hydrogen atom, alkyl, and the like, X is -O-, - S-, and the like, Y is 5- membered heteroaryl-diyl and the like, Z is optionally substituted aryl and the like, their pharmaceutically acceptable salts, or their solvates.
L'invention porte sur des composés de formule générale (I) et leurs sels et hydrates pharmacocompatibles. Dans ladite formule par exemple, R<1>, R<2>, R<3>, et R<4> représentent chacun indépendamment H, alkyle, etc.; R<5> et R<6> représentent chacun indépendamment H, alkyle, etc.; R<B> et R<C> représentent chacun indépendamment H, alkyle, etc.; X représente -O-, -S-, etc.; Y représente un hétéroaryldiyle, etc.; et Z représente aryle facultativement substitué, etc. Ces composés ont un effet inhibiteur sur le signal aval des produits du gène ras du cancer, inhibent la prolifération des cellules, et peuvent de ce fait servir de médicaments tels que des agents anti-tumoraux.
Suzuki Shinji
Takenaka Hideyuki
Tanaka Hidekazu
Ueda Kazuo
Mccarthy Tetrault Llp
Shionogi & Co. Ltd.
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