Pyrimidine derivatives intermediates for producing...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) C07D 239/34 (2006.01) C07D 403/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 498/04 (2006.01) C07D 513/10 (2006.01)

Patent

CA 2484282

Disclosed are pyrimidine compounds of formula Z: (see formula I) formula ZZ: (see formula II) formula III: (see formula III) wherein R100 is (C1-C8) alkyl, benzyl or phenyl, said benzyl or phenyl being unsubstituted or substituted, as well as a process for preparing the compound of formula Z. Those compounds are useful as intermediates for producing aminepyridine compounds of the formula: (see formula IV) in which R1 is formyl, acetyl, etc.; R2 is H, alkyl or alkoxy; and R3 is a substituted amino group such as (see formula V) in which R9 is pyrimidyl or triazinyl, useful as sorbitol dehydrogenase inhibitors.

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