C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 239/28 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2636993
Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
La présente invention concerne des composés (I) inhibiteurs de phosphatidylinositol 3-kinase (PI), leurs sels pharmaceutiquement acceptables et des promédicaments de ceux-ci ; des compositions des nouveaux composés, soit seuls soit en association avec au moins un agent thérapeutique supplémentaire, avec un excipient pharmaceutiquement acceptable ; et des utilisations des nouveaux composés, soit seuls soit en association avec au moins un agent thérapeutique supplémentaire dans la prophylaxie ou le traitement de maladies prolifératives caractérisées par l~activité anormale de facteurs de croissance, de protéines sérine/thréonine kinases et des phospholipides kinases.
Atallah Gordana
Barsanti Paul
Bartulis Sarah
Burger Matthew
Fantl Wendy
Fetherstonhaugh & Co.
Novartis Ag
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